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For people with heart conditionsIndomethacin may increase your risk of a heart attack or strokeIt may also cause higher blood pressure levels.

If you are taking this drug on anas neededbasisnot on a regular scheduleremember that pain medications work best if they are used as the first signs of pain occurIf you wait until the pain has worsenedthe medication may not work as well.

Indomethacin is a nonsteroidal anti-inflammatory drugNSAIDthat reduces feverpain and inflammationIt is similar to ibuprofenMotrinand naproxenNaprosynAleveIndomethacin works by reducing the production of prostaglandinsProstaglandins are chemicals that the body produces and which cause the fever and pain that are associated with inflammationIndomethacin blocks the enzymes that make prostaglandinscyclooxygenase 1 and 2and thereby reduces the levels of prostaglandinsAs a resultfeverpain and inflammation are reducedIndomethacin is available in an extended release formThe FDA first approved indomethacin in January 1965.

Nonsteroidal anti-inflammatory drugsincluding indomethacinmay rarely increase the risk for a heart attack or strokeThis effect can happen at any time while taking this drug but is more likely if you take it for a long timeThe risk may be greater if you have heart disease or increased risk for heart diseasefor exampledue to smokingfamily history of heart diseaseor conditions such as high blood pressure or diabetesDo not take this drug right before or after heart bypass surgeryCABG

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